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Barry said there is a wide body of research that shows brain development continues until age 25, and that nicotine addiction can have lasting effects on developing brains, so upping the legal smoking age to 21 is a no-brainer. The difference among those younger people is theres an increased risk of addiction because the brain structure is altered, Barry said

Protocol for expansion of an existing national monthly survey of smoking behaviour and alcohol use in England to Scotland and Wales: the Smoking and Alcohol Toolkit Study

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15,16 It has been suggested that creatinine, a waste product of metabolism that is primarily excreted by kidneys, is a very reliable and specific marker for assessment of renal impairment